The HYPER2 study aimed to understand:
- how prevalent HPV is among young same-sex attracted men
- how likely it is that young men will choose to have the vaccine if it is free
In this repeated cross sectional study, we compared men who have sex with men aged 16-20 years from two successive birth cohorts:
- The first cohort was before the implementation of gender-neutral vaccination (HYPER study, done in 2010-12, NCT01422356)
- The second cohort was the post-vaccination cohort (HYPER2 study, done in 2017-18, NCT03000933)
We collected samples which were tested for HPV genotypes. Participants were surveyed on their demographics and sexual practices.
We found a reduction in anal, penile, and oral quadrivalent vaccine-targeted genotypes in young MSM following the implementation of a school-based gender-neutral HPV vaccination programme. The fall in anal HPV16 and 18 may lead to a reduction in the incidence of anal cancer.
Publications
Prevalence of human papillomavirus in young men who have sex with men after the implementation of gender-neutral HPV vaccination: a repeated cross-sectional study
Chow EPF, Tabrizi SN, Fairley CK, Wigan R, Machalek DA, Garland SM, Cornall AM, Atchison S, Hocking JS, Bradshaw CS, Balgovind P, Murray GL, Chen MY
(2021), The Lancet Infectious Diseases,
Accuracy of self-reported human papillomavirus vaccination status among gay and bisexual adolescent males: cross-sectional study
Chow EPF, Fairley CK, Wigan R, Hocking JS, Garland SM, Cornall AM, Tabrizi SN, Chen MY
(2021), JMIR Public Health and Surveillance,
DOI: 10.2196/32407