This study examined if oral metronidazole with vaginal clindamycin cream (1) or a lactobacillus acidophilus vaginal probiotic containing oestriol (2) reduced bacterial vaginosis (BV) recurrence over 6 months.
We found that the BV recurrence rate at 6 months was 28%; with no difference between treatments. Combining the recommended first line therapies of oral metronidazole and vaginal clindamycin, or oral metronidazole with an extended-course of a commercially available vaginal-L.acidophilus probiotic did not reduce BV recurrence.
Publications
Efficacy of oral metronidazole with vaginal clindamycin or vaginal probiotic for bacterial vaginosis: randomized placebo-controlled double-blind trial
Catriona S. Bradshaw, Marie Pirotta, Deborah De Guingand, Jane S. Hocking, Anna N. Morton, Suzanne M. Garland, Glenda Fehler, Andrea Morrow, Sandra Walker, Lenka A. Vodstrcil, Christopher K. Fairley
(2012), PLOS ONE,