Completed in 2016
In HIV medicine we measure the immune systems strength by the number of special T cells, called CD4 T cells. We like to see patients’ CD4+ T-cell counts rise to at least 500 cells/ml. This study tried to work out why some individuals achieve this more easily than others.
We found that polymorphisms in CD14 and TLR4 are independently associated with long-term CD4 T-cell recovery in HIV-infected individuals post-antiretroviral therapy.
Publications
Polymorphisms in the CD14 and TLR4 genes independently predict CD4+ T-cell recovery in HIV-infected individuals on antiretroviral therapy
Yong YK, Shankar EM, Solomon A, Spelman T, Fairley CK, Elliott J, Hoy J, Cameron P, Kamarulzaman A, Lewin SR
(2016), AIDS,